Pharmaceutical Applications of Differential Scanning Calorimetry

Intertek ASG Laboratory, Manchester, UK

Pharmaceutical Applications of Differential Scanning Calorimetry - DSC and MDSC

State-of-the-art instrumentation offering DSC, Modulated DSC (MDSC) and Tzero DSC technologies

Thermal analysis has been an extremely important analytical tool within the pharmaceutical industry for many years. All transitions in materials involve the flow of heat (either into the sample during an endothermic event or out of the sample during an exothermic event) and DSC is the universal detector for measuring a wide variety of transitions in pharmaceutical materials.

These include measurement of:

Amorphous Structure
- Glass transition
- Detection of amorphous material in semi-crystalline compounds
Crystallinity
- Melting and crystallisation
- Purity
- Polymorphs
Drug - Excipient Interaction
Protein Denaturation
Freeze Drying

Automated Instrumentaton - Robotic Sample Handling

The new TA Instruments Q1000 DSC is a fully automated facility utilising robotic sample handling allowing rapid response to customer problems. The system is equipped with a 50 sample, 5 reference pan carousel tray, enabling samples to be run "round-the-clock". The state of the art modulated system offers improved understanding of complex thermal transitions and the sensitivity to investigate subtle thermal events such as protein denaturation or polymer glass transitions.

For further information on ASG capabilities in DSC see: