Intertek ASG Laboratory, Manchester, UK

Physical Property Measurement

Intertek ASG is able to provide a wide range of physical property measurements on aqueous solutions, fluids, liquids and solids. Applications include pharmaceutical R&D, registration of new chemicals (REACH, NONS legislation) and product development and technical support for many industry sectors. Experiments are carried out to the appropriate regulatory standards of GLP and GMP.

Typical examples of physical property measurements available to GLP and GMP standards include:

Measurements on aqueous solutions

• pH, pKa and multiple pKa
• logP
• logD
• Aqueous solubility
• Conductivity
• Redox potential
• Corrosion studies
• Partition coefficient e.g. octanol:water by shake flask or HPLC

Measurements on fluids and liquids

• Viscosity, inherent and intrinsic viscosity
• Freezing point and boiling point
• Vapour pressure
• Surface tension
• Density and specific gravity
• Refractive index and optical rotation

Measurements on crystalline and amorphous solids

• XRD, Determination of crystallinity
• Pharmaceutical thermal properties
• Differential Scanning Calorimetry - DSC and MDSC
• BET surface area measurement
• Melting point
• Density
• Electron microscopy
• Light microscopy and optical studies e.g. birefringence
• Light reflectivity and scattering measurements on solid surfaces (with integrating sphere)

For information of the prediction of physical properties see:

• Physical Property Prediction

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